Closing in on Targeted Mutagenesis
نویسندگان
چکیده
منابع مشابه
CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans
The generation of genetic mutants in Caenorhabditis elegans has long relied on the selection of mutations in large-scale screens. Directed mutagenesis of specific loci in the genome would greatly speed up analysis of gene function. Here, we adapt the CRISPR/Cas9 system to generate mutations at specific sites in the C. elegans genome.
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1990
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0190-11